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It triggers/heightens an endothelial inflammatory response in the coronary microvasculature (Paulus and Tschope, 2013)

Regulatory status and company transparency are important

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Andrologia 34:5559

Patients who show an early positive response to GLP-1 receptor agonist therapy tend to have significantly better long-term adherence and are less likely to discontinue treatment compared to those who dont see quick results

It's worth noting that the gastric emptying effect of semaglutide is most pronounced during dose escalation and may attenuate with continued use